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" Uracil found in Ryugu samples," Hokkaido University, 22 Mar 2023.
Thanks, Jacob Navia and Richard Hoover.
24 Feb 2023: more from Ryugu.
Among lncRNAs ("long noncoding" RNA transcripts of 200 or more nucleotides) only some are exported. The exported ones may act in regulatory roles, encode short peptides, or encode full-length "de novo" genes. Now we read about lncRNAs as transcripts for de novo genes that influence the growth of the human brain.
The research team in Beijing wanted to know what enabled those lncRNAs to be exported to the cytoplasm, because that looks like the crucial step for allowing a transcript to become translated into a protein. Comparing gene expression rates in humans, macaques and marmosets they said, We identified distinctive U1 elements and RNA splice-related sequences accounting for RNA nuclear export. They note that the sequences are selectively constrained.
They continue: It is also difficult to understand the process by which a de novo gene acquires its biological function. Under darwinian philosophy, you bet it is. But may we please deconstruct this issue? We know that the de novo gene has a function, but that it acquired it is not observed. It's a darwinian assumption that often leads nowhere.
The opening sentence of the research paper states Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how and why this all-or-nothing transition to functionality happens remains unclear. The word originate carries the same crippling darwinian baggage, but how the transition happens is a well-posed, timely question. The Chinese team has made good progress on that puzzle."De novo genes with an lncRNA origin encode unique human brain developmental functionality," by Ni A. An, Jie Zhang, Fan Mo, Xuke Luan et al., doi:10.1038/s41559-022-01925-6, Nature Ecology and Evolution, 02 Jan 2023.
"De novo gene increases brain size," by April Rich and Anne-Ruxandra Carvunis, Nature Ecology and Evolution, 02 Jan 2023. The de novo emergence of protein-coding genes from ancestrally noncoding sequences was long believed to be nearly impossible. However, many de novo genes have now been discovered that are of high interest because of their potential contribution to novel species-specific traits.
...De Novo Genes has more examples of genes with no detectable darwinian provenance.
Robust Software Management would allow species to acquire and deploy existing genes.
New genetic programs in Darwinism and strong panspermia asks if genes acquire, or already have their functions.
Unexpectedly, maternal mRNAs undergo global remodeling: after deadenylation or partial degradation into 3'-UTRs, they are re-polyadenylated to produce polyadenylated degradation intermediates, coinciding with massive incorporation of non-A residues, particularly internal long consecutive U residues, into the newly synthesized poly(A) tails. Moreover, TUT4 and TUT7 contribute to the incorporation of these U residues, BTG4-mediated deadenylation produces substrates for maternal mRNA re-polyadenylation, and TENT4A and TENT4B incorporate internal G residues. (Liu et al.)
This work is a fine example of the deep genomics research going on around the world. Meanwhile, I notice the lack of any useful contribution from neo-darwinism or any of its modern variants. The new findings are almost always "surprising," or "unexpected," with strained evolutionary scenarios concocted post hoc — if at all. We need a new theory of evolution.
"The James Webb Space Telescope discovers enormous distant galaxies that should not exist," by Tereza Pultarova, Space.com, 22 Feb 2023; re:
"A population of red candidate massive galaxies ~600 Myr after the Big Bang," by I. Labbé, P. van Dokkum, E. Nelson et al., doi:10.1038/s41586-023-05786-2, Nature, 22 Feb 2023. ...the amount of mass we discovered means that the known mass in stars at this period of our universe is up to 100 times greater than we had previously thought.
Thanks, Jim Powers.
The End and the Big Bang has thoughts about cosmologies that would not sterilize the universe.
In an introductory piece, Christopher Herd casually comments, The Ryugu samples contain thousands of different types of organic molecules, including amino acids. By modern consensus, the organics formed in the interstellar medium, before the solar system formed. These were incorporated into Ryugu's parent body, along with frozen water which later melted. Of course, there's another way to interpret that evidence, because complex organics are usually symptomatic of life, and liquid water is conducive to life."Analyzing asteroid Ryugu," by C.D.K. Herd [link | ToC], Science, 24 Feb 2023
"Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu," by Hiroshi Naraoka et al., doi:10.1126/science.abn9033 [link | ToC], Science, 24 Feb 2023
Thanks, Richard Hoover, who notices that three of life's amino acids analyzed in Ryugu have excesses of the L enantiomer. This implicates ancient biology, but the analysts make no comment.
Comet Rendezvous is a related section of "Can The Theory Be Tested?"
22 Mar 2023: Uracil found in Ryugu.
New genetic programs..., first posted in 2002, explains why programs seeming to have come "from nowhere" support cosmic ancestry ["strong panspermia"].
"How do pandemics begin? There's a new theory – and a new strategy to thwart them," Michaeleen Doucleff, NPR Morning Edition [link], 15 Feb 2023.
"A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia," by C.A. Sánchez, H. Li, K.L. Phelps et al., Nat Commun, 09 Aug 2022. Like snowflakes during a nice winter snow, spillovers are trickling across our population every day, says Peter Daszak, who led the study.
07 Feb 2018: More than 800 million viruses per square meter per day descend from the high atmosphere....
Viruses and Other Gene Transfer Mechanisms points to many examples of viral genes that become endogenous.
10 Feb 2023: Chandra Wickramasinghe, for his contributions to Science, Astronomy and Astrobiology, was invested into the Order of the British Empire at Windsor Castle by King Charles III.
31 Dec 2021: First announcement and press release.
Chandra Wickramasinghe: 1981 statement with links and updates
Hoyle and Wickramasinghe's Analysis of Interstellar Dust.
The Panspermia Theory, by BBC Ideas, The Open University, on Aeon, 07 Feb 2023.
Thanks, George Nickas and Google Alerts.
Bacteria... can survive many hazards, as the video affirms.
Chandra Wickramasinghe is a astrobiologist at the University of Buckingham. Milton Wainwright is a microbiologist at the University of Sheffield. I have known both of these UK astrobiologists for decades. Now they have written a book about their shared interest in panspermia.
Wainwright also knows the history of science. Right away we read about pre-socratic Greeks who thought about "seeds" everywhere. Various theories of the origin of life are mentioned, with surprising quotes from Charles Darwin, Thomas Edison and others. French philosopher Benoit De Maillet was the first "modern" proponent of panspermia, Wainwright contends. Did Mary Shelley conceive of Frankenstein after attending a lecture about lightning and the origin of life? Informative, and intriguing.
Wickramasinghe then relates how his collaboration with Fred Hoyle grew into a life in astrobiology. I know the story, and this telling is especially compelling and concise. His spectograpic investigation of interstellar dust is more sustained and penetrating than any before it, I'm sure. Of course Chandra is frustrated that the evidence for signs of biology in the dust is often dismissed without a hearing, or is rebutted with insubstantial, implausible alternatives.
The evidence for microfossils in meteorites like ALH84001, Orgueil and Polonnaruwa gets plenty of attention, as it should. Bacteria in the high atmosphere also get scrutiny, although skeptics may argue that they're from below. To flesh out the story, some scenarios are necessarily speculative, because it's uncharted territory. Me, I'm glad to see panspermia so well and boldly advocated.Life Comes from Space: The Decisive Evidence, by Milton Wainwright and Chandra Wickramasinghe, Foreword by Gensuke Tokoro, ISBN-10:9811266255, World Scientific, 2023.
Light Scattering Functions for Small particles with applications in Astronomy, by N.C. Wickramasinghe, Wiley, 1973.
Viruses and Other Gene Transfer Mechanisms has a primer and many examples of HGT.
The simplest form of life we know is a single prokaryotic cell. Nothing less could bring life to a lifeless planet. Eukaryotic cells also probably could, and viruses may easily hitchhike on any route cells might use. These microbes, frozen inside comets for example, could persist indefinitely and arrive on a planet intact, perhaps descending as dust. Multicellular life would have more trouble. That's why cosmic ancestry adopts the definition of Panspermia that we have.
But this definition is incomplete. Specialists have often noticed the space-hardiness of Tardigrades. Astrobiologist Devid Tepfer has long advocated plant seeds as vectors for panspermia. Ted Steele et al. suggest cryo-preserved embryos of larger animals may survive in comets. Moreover, life in a comet may not always be dormant. A periodic pass close to a star could warm the comet enough to melt the ice and allow cells to grow.
Even far from stars, radioactive elements with long half-lives could warm a comet interior, as Hoyle and Wickramasinghe knew. Now Richard Hoover expands on that idea, suggesting that radioactivity may allow for "the transfer of intact biospheres across interstellar and possibly intergalactic distances." He's calling it "Wet Panspermia."25 May 2021: Tardigrades can survive hard vacuum, complete dessication, ionising radiation, etc.
David Tepfer and Sydney Leach, "Plant Seeds as Model Vectors for the Transfer of Life Through Space," doi:10.1007/s10509-006-9239-0, Astrophysics and Space Science, 15 Nov 2006.
Ted Steele et al., "Cause of Cambrian Explosion - Terrestrial or Cosmic?" doi:10.1016/j.pbiomolbio.2018.03.004, Progress in Biophysics and Molecular Biology, online 13 Mar 2018.
Richard B. Hoover, "Meteorites comets, rogue planets and the distribution of biosphere" [local abstract | 25-min video begins min:46], World Conference on Basic Sciences and Sustainable Development, Belgrade, Serbia, 19-22 Sep 2022.
09 Jan 2021 ...uranium and thorium isotopes suggest the comets may have been wet for long times.
13 Jan 2023 (book review): Kevin Peter Hand thinks whole biospheres might cross a galaxy.
Introduction and ...New Questions have more about the word "panspermia."
Collcted articles frm Richard Hoover.
"Dr. Stan Franklin dies: Memphis genius pioneered 'Artificial Intelligence'" by John Beifuss, Memphis Commercial Appeal, 26 Jan 2023.
Artificial Minds by Stan Franklin, MIT Press, 1997.
Thanks for a first alert, Chip Morrison.
Astrobiology Research Trust
"Brief review about history of astrobiology" by Bruno Leonardo do Nascimento-Dias and Jesús Martinez-Frias, International Journal of Astrobiology, online 19 Oct 2022.
And Hand makes it instructive. When he sees a need, he uses helpful analogies to remind us of the relevant science. He explains how different missions and different scientists with different instruments and methods progressively enabled us to reach our current understanding of other worlds. For example, some bodies have magnetic fields that are intrinsic, some that are induced, some, none at all. Each case holds important clues about the structure of that world.
Hand can also be quite imaginative about the life that might be found in those oceans. Could an underwater civilization develop metallurgy, or advanced technology? I gladly welcome such free-thinking. He also considers at length whether life elsewhere could use entirely different chemistry from ours. I think we first need to better understand life-as-we-know-it.
I'm puzzled: why doesn't panspermia get mentioned? He wonders if inhabited moons or planets might get thrown out of orbit and "transport biospheres across the galaxy" (p 134). Heck, that's panspermia, wholesale. For finding extra-terrestrial life, he writes, "the easiest and most intuitive biosignature is perhaps the one you can judge with your own eyes: its morphology" (p 238). He must be unaware of the morphology photographed by the Opportunity rover on Mars, 27 Feb 2004. His account of the search for life by the Viking mission, 1976-1977, sticks closely to NASA's hyper-conservative party line. At least he plainly admits, "There has been only one time in the history of space exploration when looking for signs of life was the stated target of the mission [Viking]. this first time was also the last time" (p 231). If this frustrates him, he says no more about it.
Of course Hand does not stray from orthodoxy as far as I do. Still, this book moves the paradigm in the right direction. For a bonus, it's edifying and enjoyable. Recommended!Alien Oceans: The Search for Life in the Depths of Space by Kevin Peter Hand, Princeton Unversity Press, 2020.
Life on Europa, Other Moons, Other Planets? has related links.
16 Mar 2015: Ganymede has intrinsic and induced magnetic fields.
Life on Mars! has more about Viking and a link for Opportunity sol 34.
Thanks for the book, Ellen Klyce.
The trouble is, those eukaryotic genes lack any discernable neo-darwinian provenance. They're just already installed in archaea. If we ask how the genes originated, mainstream theory has nothing to offer. A better question is, Where do these eukaryotic genes come from? Apparently, they come by HGT, possibly from archaea. Before archaea, the trail vanishes abruptly. This evidence supports evolution by cosmic ancestry."Did ancient tentacled microbes kick-start complex life?" by Elizabeth Pennisi, Science, 06 Jan 2023.
"Actin cytoskeleton and complex cell architecture in an Asgard archaeon," by T. Rodrigues-Oliveira, F. Wollweber, R.I. Ponce-Toledo et al., doi:10.1038/s41586-022-05550-y, Nature, 21 Dec 2022.
07 May 2015 and 09 Oct 2015: Genes for Eukaryotic Signature Proteins in Archaea.
Viruses and Other Gene Transfer Mechanisms has more.
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