What'sNEW

19 Aug 2019
Paleologists have analyzed the Ordovician surge in biodiversity by reviewing and synthesizing the fossil and sedimentary records. They observe that simultaneous changes in temperature, atmospheric oxygen and ocean nutrients were necessary. They further conclude that rapid speciation was facilitated when populations were alternately isolated and connected, because sea level fluctuated as the South Polar ice cap shrank and grew. They treat these several developments as building blocks needed to climb a high barrier, illustrated with Legos. Although the darwinian paleologists never address any apparently sudden genetic changes, we truly enjoy the post-modern global fitness landscape.
post-modern global fitness landscape with Legos
Coordinated biotic and abiotic change during the Great Ordovician Biodiversification Event: Darriwilian assembly of early Paleozoic building blocks by Alycia Stigall et al., Palaeogeography, Palaeoclimatology, Palaeoecology, 15 Sep 2019. Early Species Developed Much Faster Than Previously Thought, Newswise, 16 Aug 2019.
Gaia introduces environmental evolution. Neo-Darwinism... discusses fitness landscapes and punctuated equilibrium.

16 Aug 2019
There may be more genes in the collective human microbiome than stars in the observable universe, and at least half of these genes appear to be unique to each individual.... Harvard Medical School, 14 Aug 2019. The Human Microbiome: 50% singletons

A medical team has begun the effort to sequence the entire human microbiome by starting in the digestive tract. The Boston doctors analyzed 3,500 samples containing almost 46 million genes. More than half of the genes were "singletons", unique to each individual, and this ratio likely extends to the entire microbiome. In any case, the number of unique, singleton genes in the human microbiome is astonishing, even to us. And the finding supports our contention that so-called "new" genes actually already exist.

The Landscape of Genetic Content in the Gut and Oral Human Microbiome by Braden T. Tierney et al., doi:10.1016/j.chom.2019.07.008, Cell Host & Microbe, 14 Aug 2019.
Microbial Fingerprinting by Ekaterina Peshiva, Harvard Medical School (+Technology Networks), 14 Aug 2019.
Thanks Thanks, Google Alerts.
Metazoan Genes Older Than Metazoa? and
Genes Older Than Earth? are related.

15 Aug 2019
Archaebacteria that contain many eukaryotic signature proteins (ESPs) have been cultured. The subject species, Lokiarchaea, were first observed in deep-sea sediments. Japanese biologists needed twelve years to culture them. Now scientists hope to ascertain the purpose of their surprising ESPs, and hope this information will help to explain the evolution of complex life.

In darwinian philosophy, genes are composed by mutation-and-selection for ongoing or incipient functions. So, plausible, non-eukaryotic functions will need to be proposed for at least some of the ESPs. (But how did the genes get the programming for their eukaryote-specific functions? Nevermind.) In cosmic ancestry, genes precede their functions. ESPs found in primitive species support this expectation.

Scientists glimpse oddball microbe that could help explain ...complex life by Jonathan Lambert, Nature, 09 Aug 2019.
07 May 2015: Lots more about Lokiarchaea. 19 Feb 2017: ESPs in Lokiarchaea and other archaebacteria.
Metazoan Genes Older Than Metazoa? cites similar evidence since 1996. Genes Older Than Earth? has more.

11 Aug 2019
A star that is "older than the universe" is baffling scientists, suggesting there might be something fundamentally wrong with the Big Bang theory.
...by Sophie Curtis, Daily Mirror (+ Sean Martin, Express), 08 Aug 2019.
The End and the Big Bang has related discussion and updates. Thanks Thanks, Karen Roberts.

10 Aug 2019
Darwin's Doubt Darwin's Doubt, by Stephen C. Meyer, has two central theses. The first is that the modern theory of evolution does not work. In 500 pages, he makes a thorough and convincing case.

The second thesis is that Intelligent Design (ID) does work. Well, if so, how does it work? When Meyer mentions causes now in operation (p 349), and titles a section A Cause Now in Operation (p 360), we become especially alert. But no causes ever appear. Meyer explains that ID is "not a strictly material process or mechanism" (p 395). He thinks it can still be scientific.

The book would probably edify anyone interested in evolution. And the false dichotomy between Darwinism and ID remains gridlocked in place. There must be another way.

Darwin's Doubt: The Explosive Origin of Animal Life and the Case for Intelligent Design, by Stephen C. Meyer, Harper One, 2013.
Evolution versus Creationism has discussion and links.
Compare Darwinism, Creationism/ID, Cosmic Ancestry

...we know that nature has been busy cross-contaminating worlds for the past 4 billion years.
Tardigrades Were Already on the Moon by Caleb A. Scharf, Scientific American, 08 Aug 2019.
Thanks Thanks, William Smith and Stan Franklin. I thought Scharf was skeptical. Anyway, good to hear.

02 Aug 2019
...the last common ancestor of all multicellular animals ...already possessed an extremely complex genome.
Symphony of genes, University of Vienna (+Newswise), 05 Aug 2019; re: Ancient animal genome architecture reflects cell type identities by Bob Zimmermann et al., Nature Ecology & Evolution, 05 Aug 2019.
Metazoan Genes Older Than Metazoa? cites similar evidence since 1996. Genes Older Than Earth? has more.

29 Jul 2019
complex organic The Enceladus data are consistent with a soup replete with highly diverse organic compounds, which could serve as chemical supply for the formation of early lifelike entities. — Three astrochemists are promoting research to identify the complex organics in Enceladus' ocean, which they believe to be a prebiotic soup. They hope that the precise mix of them could help to distinguish among several origin-of-life scenarios, namely Proteins First, Metabolism First, Lipids First (their favorite), and RNA First.
Enceladus: First Observed Primordial Soup Could Arbitrate Origin-of-Life Debate by mit Kahana, Philippe Schmitt-Kopplin and Doron Lancet, doi:10.1089/ast.2019.2029, Astrobiology, online 22 Jul 2019.

The authors curtly dismiss the possibility that the organics might already include amino acids or other byproducts of life. They are aware that many carbonaceous meteorites contain amino acids, but apparently, not that these consistently exhibit remnant lifelike chirality. Panspermia is never mentioned. And of course, in an article about prebiotic soup, the software problem is left to others.
Life on Europa, Other Moons, Other Planets? has links about candidates for hosting life, including Enceladus.
The RNA World and Other Origin-of-Life Theories has history and updated links.
The Second Law of Thermodynamics and the six "Next" pages are all about the software problem.
02 Aug 2019: George Nickas replies with comments and questions.

27 Jul 2019
Heterandria formosa ...which genes may have played a role in the evolution of the placenta of certain freshwater fish is the goal of a study by biologists mostly from Wageningen University in the Netherlands. They chose to study Heterandria formosa (pictured), because there are non-placental species in the same family, so the trail should be relatively fresh. They sequenced its genome and compared it to published genomes of three related species, to be able to identify orthologous genes among them. Ultimately they found evidence exclusively in H. formosa of five duplications, and positive selection in 18 of the orthologs. Eight of the latter are known to have placental functions in mammals. The study was sharply focussed and illuminating.
Graph from van Kruistum et al.

In one featured protein, 20 out of 224 residues showed strong evidence of positive selection (tall red or blue lines.) Only a few of these 20 were in the enzymatic binding sites (colored bars in lower box.) Most residues showed evidence of only neutral mutations without any detectable effect (grey-colored "lawn".) To us the changes in this protein look like optimization by directed mutation, an example of microevolution. Yet this and similar changes seem to be involved the evolution of placental birth — macroevolution by any definition. What can be said?

First, the study was focussed on only orthologous genes. If an H. formosa gene had no orthologs in the sister species, it was ignored. We wish the Dutch team would now ask if any acquired or newly activated DNA of any description "may have played a role in the evolution of the placenta." We think that might also be illuminating.

The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish by Henri van Kruistum et al., BMC Evolutionary Biology, 26 Jul 2019.
Neo-Darwinism... Macroevolutionary Progress Redefined... & Testing Darwinism... are related webpages.
27-30 Jul 2019: First author van Kruistum replies to our reqest for clarification. Very helpful!

23 Jul 2019What'sNEW about HGT
...the most dramatic case known of functional horizontal gene transfer ever found in complex organisms.... includes stealing more than 100 functional genes, allowing the invasive vine to latch onto and steal nutrients from the host and even to send genetic weapons back into the host. HGT is both ancestral and an ongoing process in Cuscuta.
HGT is both ancestral and an ongoing process in Cuscuta
The HGT states of each ancestral node of the species tree were inferred with two methods, Dollo and Wagner parsimony. Colored bars representing each method contain numbers of HGT gain-and-loss events for each ancestral and terminal node. (Figure and legend adapted from Yang et al.)
Convergent horizontal gene transfer and cross-talk of mobile nucleic acids in parasitic plants by Zhenzhen Yang et al., Nature Plants, 22 Jul 2019. These lines of evidence all point to ...transfer of intact genomic DNA, including introns.
Parasitic plants steal genes to become better parasites by Nick Carne, Cosmos, 23 Jul 2019.
Viruses and Other Gene Transfer Mechanisms has lots about the role of HGT in evolution.
Thanks Thanks, Stan Franklin and Google Alerts.

26 Aug 1996: Arlo 'n' Janis features life on Mars. Thanks Thanks, Polly Cooper. We shoulda posted this long ago.

22 Jul 2019
Pluto observations reveal complex organics on a small body ...in the outermost regions of the Solar System.
Prebiotic Chemistry of Pluto by D.P. Cruikshank et al., Astrobiology, online 16 Jul 2019.
(How do they know that the organics are prebiotic?)

21 Jul 2019What'sNEW about HGT |
More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses — from research asking what happens when DNA methylation is lost in human cells. Of interest to us, specific silent transposons may be activated, move, and affect genes that are important in the development of nerve cells.
...the darker parts of our genetic heritage, Lund University (+Science Daily), 19 Jul 2019. Thanks Thanks, Martin Langford.

Plant viruses may be reshaping our world, ASU (+PhysOrg.com), 17 Jul 2019. Thanks Thanks, Google Alerts.
If all of the virus genes were laid end-to-end, they would stretch 250 million light-years.

18 Jul 2019What'sNEW about HGT |
Red Algae Steal Genes from Bacteria to Cope with Environmental Stresses, Rutgers Today (+Newswise), 16 Jul 2019.
The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions by Alessandro W Rossoni et al., doi:10.7554/eLife.45017, eLife, 31 May 2019.
Making an argument for the importance of HGT in eukaryote (specifically, Cyanidiales) evolution, as we do here, requires that three major issues are addressed: a mechanism for foreign gene uptake and integration, the apparent absence of eukaryotic pan-genomes, and the lack of evidence for cumulative effects (Martin, 2017). The latter two arguments are dealt with below but the first concern no longer exists. (Could the numberless ORFan genes, in viruses for example, make up much of the eukaryotic pan-genome? And we see plenty of cumultive effects.)
Viruses and Other Gene Transfer Mechanisms has lots about the role of HGT in evolution.

Hayabusa2 touched down on Ryugu to collect material from beneath the surface.
Japanese spacecraft probes asteroid's guts for first time, Nature News, 10 Jul 2019.

11 Jul 2019
Gary Ruvkun, a principal investigator in the Search for Extraterrestrial Genomes (SETG), openly advocates panspermia in a recent interview. We welcome his message, with two minor reservations. First, he is obligated to concede that methane "can be produced by various chemical reactions." As Fred Hoyle once commented to us, if methane could be readily made chemically, the Nazis would have won World War II. Second, Ruvkun cannot safely oppose standard big-bang dogma. Still, for the origin-of-life, he comments that he would rather have "a hundred billion years of time or a thousand billion years of time. That would be more satisfying." To efficiently look for life beyond Earth, he wants to send DNA sequencing equipment to Mars. Great idea!
What If Life Did Not Originate on Earth? by Isaac Chotiner, The New Yorker, 08 Jul 2019.
Thanks Thanks, Glenda Ruby. 06 Jan 2017: more on Ruvkun.

The interview led us to his recent TED-style lecture explaining how genomics and early life point to panspermia:
Gary Ruvkun: Breakthrough Discuss 2019, YouTube, 17 Apr 2019.

On the same podium Robert Zubrin talks about DNA as a way to transmit coded information through space. He suggests that propaganda might motivate extraterrestrials to advertise to other worlds. We weren't convinced, but he soon mentions propagation, which life does instinctively, naturally. Plenty to learn from Zubrin.
...Interstellar Communication with Microbes..., YouTube, 17 Apr 2019. 21 Dec 2017: more on Zubrin.
How is it Possible? includes our early speculations about intentionally undertaking panspermia to avoid extinction.

10 Jul 2019What'sNEW about HGT |
Transformed pillbugs ...a large insertion of DNA from the endosymbiont bacteria Wolbachia ...integrated itself directly into the pillbug chromosome, essentially creating an entirely new sex chromosome via horizontal gene transfer.

Before a bacterial gene can even operate in a eukaryotic cell, it has some major biological hurdles to overcome. It must acquire introns, a promoter sequence, and a termination sequence. It also has to be able to interact fruitfully with existing host genes. ...Researchers are trying to understand how this enormous leap occurs.

...against slim odds, some of these bacterial genes have introduced novel and critical functions to their new hosts. These transfers, say researchers, are an overlooked source of fodder for evolutionary transformation in complex organisms.

Horizontal gene transfer (HGT) is not overlooked in cosmic ancestry. We think it is essential for evolutionary progress. We highly recommend the new open-access review article by Viviane Callier.

...Gene transfers from bacteria and viruses may be shaping complex organisms, doi:10.1073/pnas.1909030116, by Viviane Callier, PNAS, 09 Jul 2019.
Viruses and Other Gene Transfer Mechanisms is our main related webpage.
Robust Software Management in Genomes begins our attempt "to understand how this enormous leap occurs."

09 Jul 2019
Astronomers and cosmologists are beginning to promote the likelihood of interstellar panspermia. Yesterday Harvard publicised a calculation by members of its astronomy department showing that asteroids may be accelerated from the galactic center fast enough to carry life throughout the Milky Way galaxy.
Study suggests asteroids might play key role in spreading life by Peter Reuell, posted on Physorg.com (originally Harvard Gazette), 09 Jul 2019. Thanks Thanks, Ted Steele. 11-15 Oct and 09 Feb 2018: more about this study.

Three weeks ago another astronomer reported that neighboring stars may swap life-bearing cometary material frequently. We welcome endorsements of panspermia, but these recent studies are only about the transfer of physical material. It would be fanciful to assert that life is out there without the pioneering work by Fred Hoyle (1915-2001) and Chandra Wickramasighe (b. 1939). Beginning in the 1960s, they made careful spectrographic analyses of interstellar dust. By 1980 they had found solid evidence for organic molecules and even whole bacteria in the dust. Their research gave interstellar panspermia its most substantial support.
Hoyle and Wickramasinghe's Analysis of Interstellar Dust has an historical outline.
04 July 2019: Chandra Wickramasinghe reviews the development of cometary panspermia theory.
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